FHR-5, Human, ELISA kit

This human FHR-5 ELISA is used for the quatification in serum and plasma samples.

Complement Factor H-related protein 5 (FHR-5) plays an important role in complement regulation. Predominantly synthesized in the liver, but monocytes, macrophages, and dendritic cells also contribute. With a molecular weight of approximately 65 kDa, FHR-5 closely resembles Complement Factor H (CFH), a key regulator of the complement system. Its primary function involves controlling the alternative pathway (AP) of the complement system.

FHR-5 binds to various host ligands, including C3b, heparin, C-reactive protein (CRP), and Pentraxin 3 (PTX3). It also interacts with extracellular matrix components. It actively promotes alternative pathway activation on cell surfaces, offering a scaffold for AP C3 convertase assembly. Additionally, it competes with Factor H (FH) for ligand binding, which may influence FH’s regulatory functions.

FHR-5 plays a significant but complex role in disease. Genetic variations in the CFHR5 gene lead to atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD). Furthermore, its presence in both circulating and glomerular forms is linked to IgA nephropathy (IgAN) and familial C3 glomerulopathy (C3G). However, the specific role of FHR-5 in these conditions remains under debate, and other genetic factors may also contribute, underscoring the necessity for further research in this area.

Human FHR-5 can be measured with our HK3007 assay, designed to precisely quantify this intriguing glycoprotein.